This presentation describes how the US led the international cooperation between 16 nations, including Russia, in developing the International Space Station (ISS), which has been continuously occupied for two decades. Not a description of detailed construction history, this talk focuses on the challenges of culture, language, and technical approaches in developing ISS training, operations, and safety for astronauts and cosmonauts. Information about NASA and commercial programs for crew transportation, Moon, Mars, and space tourism will be included.